July,2010

CLEAVER SCIENTIFIC NEW CATALOGUE

PLEASE CONTACT US TO REQUEST COPIES OF THE NEW CLEAVER SCIENTIFIC CATALOGUE

CLEAVER SCIENTIFIC FLIES THE FLAG FOR UK SCIENTIFIC MANUFACTURING

Laboratory supply specialists CLEAVER SCIENTIFIC (CSL), has just released the latest edition of its product catalogue and this new edition represents a three-fold expansion in content. The catalogue includes the widest range of innovative products, all individually showcased on every page.

Originally acknowledged as a specialist in electrophoresis products, Cleaver Scientific now offers everything from precision manufactured gel tanks to chemicals, gel documentation systems, along with general laboratory and radiation safety products. New products include the microDOC™ which is now assembled in the UK. This includes the highest pixel resolution camera available for an entry-level gel documentation system. It is supplied complete with basic analysis software and a UK made transilluminator. Options include, small, compact systems for high throughput electrophoresis, low voltage systems for education applications, plus affordable high quality power supplies that are also assembled in the UK.

Cleaver Scientific also offers a comprehensive range of vertical and horizontal gel electrophoresis packages, along with UV sterilisation cabinets which serve as a low-cost alternative to a clean room, plus dry baths & stirring water baths, UV cross linkers and hybridisation incubators.

Alan Phillips, Sales Manager comments, “The new Cleaver Scientific catalogue illustrates how far the company has progressed in its six year existence.

Apart from being largely UK manufactured our products are acknowledged for their quality and ease-of-use in more than 80 countries worldwide”. He continued, “We aim to set the bench mark in novel solutions for electrophoresis and related techniques. Our new high throughput tanks are ideal for easy loading and identification of large numbers of samples on gels and when used in conjunction with our Gel cutting tips and Safecloner represent the most convenient, safest and DNA damage-free way to clone DNA.”

June,2010

INCUBATORS PROVIDE OPTIMUM CHOICE AND FLEXIBILITY

INCUBATORS PROVIDE OPTIMUM CHOICE AND FLEXIBILITY

A range of compact, space-saving benchtop incubators which provide excellent choice and flexibility to the laboratory scientist are now available from laboratory supply specialists CLEAVER SCIENTIFIC (CSL). These incubators, or hybridisation units, provide a chamber temperature from ambient to 85ºC and are ideal for many laboratory tasks, such as cell and tissue culture applications.

The range encompasses 21 models which all feature microprocessor control of temperature in precise 0.1ºC increments as well as continuous and programmable timer function which is easily viewed within a 2.6” LCD screen. Advanced ventilation design technology maintains accuracy to within ±0.2ºC.

The standard incubator model is supplied with stainless steel mesh shelves, while the more sophisticated options are available with specialist vortex, orbital, rocking or reciprocal shaking platforms. All of the incubators (except the basic model), can be supplied with hybridisation rotisseries for enhanced function. They are compact and stackable, requiring only a small footprint ensuring maximum space-saving and multi-tasking for the busy, modern laboratory.

April,2010

EFFECTIVE PROTECTION FROM RADIOACTIVE COMPOUNDS

Where life science research laboratory applications and techniques involve radioactive compounds, safe and effective protection for operatives is an essential requirement. For example, techniques involving either beta or gamma emitting materials used in the detection of nucleic acids and proteins, or others such as radioimmunoassay and metabolic studies.

To meet this requirement laboratory supply specialists CLEAVER SCIENTIFIC (CSL) has developed a range of acrylic radiation shielding products, which is acknowledged as being not only one of the largest, but also one of the few ranges of these type of products available in the UK. The range includes over 120 products, including shields, boxes, racks, waste bins, spillage trays and cabinets.

Flexibility and low cost are important requirements for many customers and CSL meets this demand by offering custom-built shields and boxes that are manufactured in a variety of shapes and sizes to match any application or budget. Its storage boxes are ideal for they may hold any type of container ranging from micro-centrifuge tubes to scintillation vials. Drawstring heavy-duty waste bags are also available, while free standing bench top bins with hinged lids and anti-slip feet are ideal for short term storage of radioactive materials.

In addition to the standard 10-mm-thick beta protection and 12mm thick lead impregnated gamma protection shielding is 35mm thick lead impregnated shielding, which provides gamma attenuation equivalent to 1.5-mm-thick lead.

This may be offered in 70-mm-thick shielding that offers gamma attenuation equivalent to 3.0-mm-thick lead.
The key features of CSL protection products are: clear optical construction for unobstructed view; a choice of angle to suit location; the availability of most shields in small and large sizes; large flat base models for under-bench protection and curved base models compatible with safety spill trays; plus boxes and bins available with hinged lids in a variety of designs and sizes. Finally, Cleaver Scientific can provide a DuoShield specifically for those applications which require safe protection from both beta and gamma emissions.

March,2010

SMOOTH, VARIABLE SPEED VORTEXER IS COMPACT & LIGHTWEIGHT

Smooth, fast and efficient mixing with minimal vibration across all speeds is an important requirement for many laboratory applications and the new variable speed Vortex Mixer from laboratory equipment specialists CLEAVER SCIENTIFIC is an ideal solution. Unlike other vortex mixers which use elliptical orbits, the VX-200 deploys a true circular orbit mixing technique which facilitates uniform sample vortexing, even at low speeds.
The CombiCup™ head, which is supplied as standard, accepts many different tube sizes, while the unique over moulding technology used in its manufacture provides a robust, sturdy core with non-slip TPE that fits optional heads for microplates, PCR strip tubes, 15ml and 50ml tubes and blood vials.
The VX-200 can be used in ‘touch’ or ‘continuous mode’; touch mode being activated by simply depressing the sample head and then stopped by releasing the pressure. Other features include an optimised counter-balance system which minimises vibration and movement of the mixer during operation.
However, despite these features and robust design the mixer is compact and lightweight, measuring 14cm x 16cm x 13cm and weighing just 2.2Kg enabling the mixer to be easily transported and used in laboratories where space is restricted. The mixer, which is safe for use in temperature controlled environments, is available in two power / speed options, 115V producing between 0-2850 RPM and 230V which provides between 0-3400RPM.

February,2010

COMPACT AND ECONOMICAL DRY BATHS

Compact, easy-to-use and offering excellent value for money are among the key features and benefits of the cube digital dry baths available from laboratory equipment specialists CLEAVER SCIENTIFIC (CSL). Available as single and dual block models, the baths are suited to a variety of applications. For example: restriction digestion, BUN, melting agar, coagulation studies, hybridisation, Hot Start PCR® reactions and DNA denaturation.

The baths have interchangeable quick-change blocks, fast heat-up times and reproducible temperature uniformity and accuracy. Also, as a result of their impermeable moulded aluminium alloy block and chamber construction, each cube dry bath may also be adapted as a mini water bath incubator if desired.

They also feature a digital microprocessor controller for accurate temperature control in 0.1°C increments from ambient +5°C to 150°C. Rapid and easy programming is facilitated by the easy to use arrow keys on the sloped front panel, while both the temperature and running time are shown simultaneously on the conspicuous dual digital LCD display. Two software options are available for data logging to a PC and computer control.

Also available in single and dual block formats, CSL’s standard dry bath incubators include many of the features of the Cube range, including microprocessor control, a wide temperature range ambient +5°C to 150°C, identical quick-change block compatibility, and optional PC control software for dry bath operation and real-time data logging.

For clarity, only temperature or time is shown in the bright digital LED display at any one time. An optional probe is available for temperature measurement of samples.

January,2010

ULTRA-COMPACT GEL DOCUMENTATION SYSTEM TICKS ALL THE BOXES

The popular CSL MicroDOC ultra-compact and easy-to-use gel documentation system is now available with software and a choice of transilluminators in either 21 x 21cm or 21 x 26cm sizes. Available through CLEAVER SCIENTIFIC, the MicroDOC high resolution 32 bit RGB system incorporates the latest Canon digital camera which is capable of producing high quality images with resolution up to 14.7 mega pixels.

The MicroDOC system is designed for optimum flexibility and enables a wide variety of images to be viewed from a new larger high definition 8” TFT liquid crystal colour display. These images can be captured from agarose gels, other fluorescent gels, colorimetric gels, auto-radiography film and blotting membranes.

The MicroDOC includes a 55mm ethidium bromide filter with a built-in safety switch to allow the UV Transilluminator to be turned-off when the door is open, while files can be saved in a variety of formats ready for transfer to computer systems for storage and further analysis. The system now includes a 2GB flash card and reader, providing double the previous image capacity, enabling easy data transfer. Printing can be performed directly from MicroDOC using the included USB cable which also permits direct connection to a computer.
The compact and competitively priced MicroDOC system will be particularly suited to laboratories where space and budgets are limited as it can be used completely independently of a PC.

For added convenience, printing of saved or live images can be performed directly from the MicroDOC. In addition, Cleaver Scientific can supply thermal printers, such as the competitively priced Mitsubishi P93 Series.

November,2009

FASTER, EASIER SAMPLING FROM 96-WELL PLATES

Saving time and minimising effort in the laboratory, yet producing products which contribute toward high quality results, are the main objectives behind the development of the CLEAVER SCIENTIFIC (CSL) range of electrophoresis products. The range now includes the compact CSL multiSUB Midi 96 and 96 Stretch system which can be used in conjunction with samples from 96 well plates to allow direct loading and easy identification of samples.

With an average run-time of just 15 to 30 minutes, the Midi 96 system enables rapid identification of samples, with direct and rapid sample loading facilitated using 8 channel pipettes. Four comb options are available – 8MC with 1 or 2 marker lanes in 1 or 1,5mm thickness. The run length between lanes is 1.8cm for the MSMIDI96 version and 3.6cm for the Stretch version. The Stretch version also has the capability for increased capacity allowing samples from two Micro titre plates to be loaded.

Flexibility and choice are among the key features of the CSL range of gel electrophoresis tanks which comprises horizontal and vertical gel electrophoresis tanks, blotting systems, comet assay, cellulose acetate, 2-D systems, power supplies, DNA sequencers and gel documentation systems. These are suitable for a variety of DNA, RNA and protein gel electrophoresis applications and analysis.

Constructed using the latest injection moulding technology and made from durable, resistant materials, the tanks offer innovative and easy-to-use leak-proof gel casting to save time in the laboratory. Among the innovations and choices offered are more options for gel size, sample number and volume, along with five thicknesses of comb. Also, there are more preparative, high sample number and multi-channel pipette compatible comb options and combs which are height adjustable and warp proof.

There are also options for the type of comb with convenient double-sided, two combs in one and combination combs which include a loading guide on the reverse aiding sample loading. Gel sizes offered range from 7cm x 7cm up to 33cm x 45cm. Cleaver Scientific also offer many other options to enhance the visibility of the wells during gel loading, such as using an inert dye which is used to stain the stacking layer of protein gels.

Most tanks in the range have the option of rapid set-up cooling without the need for a chiller. These save time and expense in the laboratory and allow high resolution results to be achieved with the minimum of time and effort. For the economy conscious, most gel tanks have the option of buffer saving and casting of multiple gels at the same time, which also provides increased consistency.
Cleaver Scientific also offer products which provide important benefits for post electrophoresis applications, such as their popular gel cutting tips which are an extremely useful tool for gene cloning. Finally, to complete their range of tanks and systems, Cleaver offer a range of power supplies with increased current capacities. These enable high intensity blotting and the connection of multiple gel tanks to one power supply, without compromising run conditions whilst also saving on bench space and cost.

September,2009

Uv STERILISATION CABINETS PROVIDE A ‘MINI CLEANROOM’ FACILITY

Where laboratories require a compact, yet safe, nucleic acid-free environment which provides an easily accessible area for setting-up PCR (Polymerase Chain Reactions), uvCAB UV Sterilisation Cabinets from CLEAVER SCIENTIFIC (CSL) are an ideal solution, particularly when space is at a premium.

Similar to having a ‘mini-cleanroom’ in your laboratory, CSL UV Sterilisation cabinets minimise the potential for PCR reaction contamination. They include powerful UV lights which serve to denature nucleic acids in 5 to 30 minutes making them suitable for decontamination of equipment used for setting up PCR reactions. The lights are timer controlled and there are safety switches on the cabinet doors which automatically turn-off the UV lights when opened preventing user exposure to UV light.

The cabinets also act as an efficient shield against beta radioactive emissions and can therefore be safely used with isotopes, such as 32P. The cabinets also include a white light which provides excellent visibility when working inside the cabinet.

uvCAB cabinets are available in two sizes. The Maxi version offers a large working space measuring 660 x 560 x 420mm (H x W x D) and offers a good sized cabinet for setting-up and also storage of PCR reactions along with the pipettes, racks and other equipment. For laboratories where space and budgets are particularly limited, the Mini Cabinet is ideal. It measures just 400 x 560 x 350mm (H x W x D).

Accessories such as DNA and RNA removing solutions and compatible safety trays with disposable liners for use with both sizes of cabinets are also available.

July,2009

NEW STAINS FOR PROTEIN DETECTION FROM CLEAVER SCIENTIFIC

Three new protein stains for post-electrophoretic protein detection, which are reversible and claimed to be more sensitive than many colorimetric and fluorescent stains currently available on the market, are now available from CLEAVER SCIENTIFIC (CSL). Available in blue, green and red colours as CSLblue, CSLgreen and CSLred, these protein stains can detect a minimum 1-3ng of protein per square millimetre of gel.

Staining is simple, with the gel just immersed directly within the CSLblue, CSLgreen or CSLred stain for approximately one hour which is no longer than is necessary for other commercial stains, such as Coomassie and SYPRO Ruby. However, destaining is generally faster and may be completed within as little 30 minutes.

Visualisation of the gel is performed with a visible light filter on a standard UV transilluminator, using the preferred lower energy 312 or 365nm wavelengths. Membranes following protein transfer may also be visualised in a dark hood after staining with CSLgreen.

All three CSL stains are based on metal chelates and will remain stable for at least one year without loss of sensitivity if stored in a refrigerator. CSLblue is a colorimetric chelate stain, strongly visible under white light and at least twice as sensitive as Coomassie blue. At visible wavelengths, CSLgreen produces a fluorescent signal with an intensity which is greatly increased in the presence of detergent to the extent that it is four times more sensitive than Coomassie blue. CSLred’s fluorescence intensity also increases in the presence of detergent which results in it being able to detect protein with at least two-fold greater sensitivity than SYPRO Ruby. All three stains are reversible enabling them to be removed to allow the gel to be subjected to other post-electrophoretic applications. They can also be reused up to three times for repeated staining. Typical applications include post-electrophoretic staining of protein gels and blots and for imaging following 2-D electrophoresis.

June,2009

RADIATION SAFETY PRODUCTS PROVIDE OPTIMUM PROTECTION

Safe and effective protection from radioactive compounds is an essential requirement in certain life science research laboratories, for example those handling either beta or gamma emitting materials used in the detection of nucleic acids and proteins, or other techniques, such as radioimmunoassay and metabolic studies.

CLEAVER SCIENTIFIC (CSL) manufactures the largest range of acrylic radiation shielding products from their facility in the UK. CSL has developed a wide range of over 120 Radiation Safety Products which provide optimum protection for laboratory personnel involved in applications where either Beta or Gamma emitting compounds are used. The range includes; shields, boxes, racks, waste bins, spillage trays and cabinets.

Flexibility and low cost are important requirements for many customers and CSL meet this demand by offering custom-built shields and boxes which are manufactured in a variety of shapes and sizes to suit most applications and budgets. The storage boxes are ideal for waste material and samples. Interchangeable inserts hold various sizes of tubes, such as micro-centrifuge, centrifuge tubes, scintillation vials, universals, cryotubes and falcon tubes. Drawstring heavy-duty waste bags are also available. Free standing bench top bins with hinged lids and anti-slip feet are ideal for short term storage of radioactive materials.
In addition to the standard 10mm thick beta protection and 12mm thick lead impregnated gamma protection shielding is 35mm thick lead impregnated shielding, which provides gamma attenuation equivalent to 1.5mm thick lead. Also available is 70mm thick shielding that offers gamma attenuation equivalent to 3.0mm thick lead.

The key features of these protection products are: clear optical construction for unobstructed view; a choice of angle to suit location; the availability of most shields in small and large sizes; large flat base models for under-bench protection and curved base models compatible with safety spill trays; plus boxes and bins available with hinged lids in a variety of designs and sizes. Finally, Cleaver Scientific can provide a DuoShield specifically for those applications which require safe protection from both beta and gamma emissions.

April,2009

FAST, FLEXIBLE AND CONVENIENT ELECTROPHORESIS

Saving time and minimising effort in the laboratory, yet producing products which contribute toward high quality results, are the main objectives behind the development of the CLEAVER SCIENTIFIC (CSL) range of electrophoresis products.

The range now includes the compact CSL multiSUB Midi 96 system which can be used in conjunction with samples from 96 well plates to allow direct loading and easy identification of samples. With an average run-time of just 15 to 30 minutes, the Midi 96 system enables rapid identification of samples, with direct and rapid sample loading facilitated using 8 channel pipettes.

Flexibility and choice are among the key features of the CSL range of gel electrophoresis tanks which comprises horizontal and vertical gel electrophoresis tanks, blotting systems, comet assay, cellulose acetate, 2-D systems, power supplies, DNA sequencers and gel documentation systems. These are suitable for a variety of DNA, RNA and protein gel electrophoresis applications and analysis.

Constructed using the latest injection moulding technology and made from durable,
resistant materials, the tanks offer innovative and easy-to-use leak-proof gel casting to save time in the laboratory. Among the innovations and choices offered are more options for gel size, sample number and volume, along with five thicknesses of comb. Also, there are more preparative, high sample number and multi-channel pipette compatible comb options and combs which are height adjustable and warp proof.

There are also options for the type of comb with convenient double-sided, two combs in one and combination combs which include a loading guide on the reverse aiding sample loading. Gel sizes offered range from 7cm x 7cm up to 33cm x 45cm.
Cleaver Scientific also offer many other options to enhance the visibility of the wells during gel loading, such as using an inert dye which is used to stain the stacking layer of protein gels.

Most tanks in the range have the option of rapid set-up cooling with no chiller required. These save time and expense in the laboratory and allow high resolution results to be achieved with the minimum of time and effort. For the economy conscious, most gel tanks have the option of buffer saving and casting of multiple gels at the same time, which also provides increased consistency.

Cleaver Scientific also offer products which provide important benefits for post electrophoresis applications, such as their popular gel cutting tips which are an extremely useful tool for gene cloning.

Finally, to complete their range of tanks and systems, Cleaver offer a range of power supplies with increased current capacities. These enable high intensity blotting and the connection of multiple gel tanks to one power supply, without compromising run conditions whilst also saving on bench space and cost.

March,2009

SAFER, DNA DAMAGE FREE VISUALISATION OF GELS WITH SAFECLONER

A new device which enables safe, UV-free visualisation of EtBr, SYBR Green and SYBR safe gels, is now available through electrophoresis specialist CLEAVER SCIENTIFIC (CSL). SafeCloner means DNA bands can now been seen safely and clearly, using high efficiency LED illumination and filter glasses.

Eliminating harmful UV is an important benefit of SafeCloner, its LED illuminator removes the dangers of conventional transilliminator use, such as stray UV, which, if unchecked, can cause retinal damage. It also eliminates the dangers to technicians of exposing their hands to harmful UV radiation, which can increase the risk of skin cancer and accelerate aging, whilst also damaging DNA.

LED illumination does not damage DNA even after long exposure times. Also, the cloning efficiency of DNA fragments eluted from gels exposed to SafeCloner is significantly improved compared to the cloning efficiency of DNA isolated from traditional UV-illuminated gels. SafeCloner’s blue epi-LED illumination and special filter glass result in greater sensitivity and contrast than longer wavelength 365nm transilluminators. SafeCloner can also be used with inexpensive gel documentation products such as the Cleaver Scientific Microdoc unit.

February,2009

COMPACT, FAST HEATING DRY BATHS SAVE TIME AND SPACE

For many laboratories saving time and space, due either to financial or other operational constraints, are important objectives. With these requirements in mind electrophoresis and laboratory equipment specialists CLEAVER SCIENTIFIC LTD (CSL) have introduced a new range of compact, rapid-heating microprocessor controlled dry baths.

These digital dry baths are suitable for a wide range of tasks in most laboratories, including clinical, histology and molecular biology applications. They provide users with a heating speed of ambient to 100ºC in just 12 minutes and so reduce inconvenient waiting for the correct temperature to be reached.

They offer precise, accurate control of the integral high wattage heaters thanks to the easy-to-use digital microprocessor control panel. Also, there is no need to check or re-adjust the thermometer afterwards. With the block chamber constructed from moulded aluminium, these baths offer improved heat uniformity because of the perfect contact with the base of the interchangeable blocks whilst also retaining heating efficiency because the moulded construction does not warp over time

A user calibration function allows easy calibration to suit in-house standards and requirements as and when required, while an RS232 port records block temperature activity. A data-logging software package which links to a PC can also be supplied. Another important feature is the stainless steel block chamber within the unit which acts as a heat sink and promotes uniform transfer of heat from the heating elements to all the interchangeable blocks. This results in optimum consistency for all the samples because they are subjected to the same temperature, regardless of their position in the block.
A wide choice of different types of block for different types of tube, are available.
CSL dry baths also provide users with added versatility because they can also be used as water baths, which is achieved simply by removing the block and filling with distilled water.
Two inter-compatible models are available in the range, a single block unit which will accept all of the standard blocks and a dual unit which will accept two standard blocks or one specially designed block to suit a specific application. Both models are supplied with a block filter as standard.

January,2009

A SMALL GEL TANK FOR HIGH THROUGHPUT ELECTROPHORESIS SAVES TIME AND SPACE IN THE LABORATORY

A new gel system, capable of running 4 gels in one tank, is the latest product from CLEAVER SCIENTIFIC - the expert manufacturer of electrophoresis products. The compact CSL multiSUB4 system is designed to run up to 1200 samples in 4 vertically stacked gel trays to achieve high throughput electrophoresis, while maintaining the space-saving advantages offered within the laboratory by a small unit. Each gel tray is UV-transparent for the easy visualisation of samples directly on the transilluminator following electrophoresis, while the inclusion of 4 double-sided multi-channel pipette compatible combs allows rapid sample loading from 96-well gel trays and thermal cycler blocks.

Two formats of double-sided combs are available - one with one marker and one sample lane for the large scale-up of nucleic acids that may be turned over for a 12-sample throughput if required, and another included with the unit which offers both an 8- and 18-sample throughput. The gel trays included with the CSL multiSUB4 are 12 cm in length, while trays 6 and 18 cm in length are also available for shorter and longer separations if preferred. The CSL multiSUB4 is the ideal rapid screening accessory for DNA mini-preps prepared in 96-well plates or PCR products from thermal cycler blocks.

November,2008

ELECTROPHORESIS SYSTEMS DIRECTLY MATCH 96 WELL PLATE FORMATS

Two new Gel Systems which are ideally suited for high throughput electrophoresis of PCR products from 96 well microtitre plates are the latest addition to the CLEAVER SCIENTIFIC (CSL) range of products. The compact CSL multiSUB Midi 96 system is designed to be used in conjunction with samples from 96 well plates to allow direct loading and easy identification of samples. The run length between samples is 17mm. Also available is the multiSUB MIDI96 stretch which has a run length of 34mm for those requiring extended separations.

With an average run-time of just 15 to 30 minutes, the Midi 96 version allows rapid identification of samples. Direct rapid sample loading is facilitated using 8 channel pipettes. Two different types of comb are available - one with 8 wells and one additional lane for DNA markers and one with 8 wells plus two additional lanes for markers. Custom made combs to other formats are also available on request.

The buffer volume of the Midi 96 is just 300ml. This can be reduced using convenient buffer saver blocks to 200ml. Rapid leak proof gel casting is facilitated using end dams and an all in one comb block, no placing of individual combs is required.
Other convenient features include well visualisation aids and loading guides for easy sample loading.

October,2008

COMPACT, INCUBATION OVENS ENABLE MULTI-TASKING

A high degree of temperature uniformity utilising digital microprocessor control, versatility, capacity and choice, are the key features and benefits of a new range of incubation ovens introduced by CLEAVER SCIENTIFIC. These compact, stackable incubators require only a small footprint ensuring maximum laboratory space saving and enable multi-tasking for the busy, modern laboratory.

The incubators offer fast interchange between rotisserie and a variety of other shaking options including rocking, reciprocal, oribital and vortex. Other features include; digital microprocessor control, chamber temperature range of ambient to 85ºC and a uniform temperature chamber accuracy of ± 0.2ºC.

Available in no less than 10 options, CSL incubators have chamber dimensions of 340mm x 260mm x250mm, overall dimensions of 360mm x 440mm x 430mm and weigh approximately 25Kg

September,2008

EASY-TO-USE BENCH SPACE SAVING DIGITALLY CONTROLLED LCD DRY BATHS

EASY-TO-USE BENCH SPACE SAVING DIGITALLY CONTROLLED LCD DRY BATHS
New from Cleaver Scientific - The Cube Range of Digital Dry Baths.

Ideal for use in a variety of
applications including; restriction digests, BUN, melting agar,
Coagulation studies, Hybridization, Hot Start Thermo-Cycled reactions and for denaturing DNA, the range includes single
and dual block models, along with a comprehensive range of
interchangeable blocks for many different sized tubes and vesicles.

These compact and competitively priced
easy-to-use systems incorporate the essential features you need.

The quick-change blocks have fast heat-up times and excellent block
temperature uniformity.

Due to their moulded aluminium chambers, both large and small models can be filled with water to act as mini water baths.

Each unit incorporates a Digital microprocessor
controller and is designed to accurately control
temperature from ambient +5 to 150 degrees centigrade.

The digital dual display shows both the temperature and the running time simultaneaously, for added user convenience.

There are two software options, for data logging to a PC and for computer control of the Dry bath.


Among the user benefits of these Digital baths are rapid and easy programming facilitated by the easy to use arrow keys on the front sloped panel and precise, accurate control of the integral high wattage heaters thanks to the easy-to-use digital microprocessor control panel.

August,2008

BENCHTOP FERMENTATION SYSTEMS FOR OPTIMUM CONTROL

Two types of programmable fermentation systems are now available from CLEAVER SCIENTIFIC. They both offer a high level of performance and reproducibility and are ideal for growing a wide variety of cell types. These include microbes, yeast and fungi, as well as mammalian, insect and plant cell lines.

Both models are designed for bench-top use: the CSL-FS-S modular, a small scale fermentation system for one vessel of up to 1.5 litres, and the CSL-F1 for four different sizes of fermentation vessel, covering capacities of 3, 5, 7 or 10 litres or for dual vessels. Double jacket vessels are available for mammalian cell culture.

Each system includes a built-in, 15 step programmable software package and integrated control panel, which enables real-time recording and communication between the fermentation system and the connected PC and allows the setting of various conditions including Cascade and Acid - Start.

The controller can be set to keep the microbes in the various growth phases for maximum yield, accommodating batch, fed batch and continuous fermentation as required. A pH probe enables automatic control of either acid or base input via peristaltic pumps and the DO probe controls the aerator. A validation package is also available as an optional extra.

The smaller, modular CSL-FS system is ideal for smaller scale fermentations, providing maximum flexibility and enabling different components to be assembled depending on user requirements. These include tetra peristaltic pumps which are fully and individually controllable.
Cont…
Many of the accessories can be added as optional extras to the modular CSL-FS system, including pH and DO probes and this ensures an affordable alternative to traditional culture methods.

July,2008

GLOVE BOXES PROVIDE A CONVENIENT, CONTROLLED ATMOSPHERE

A new range of glove boxes which provide a convenient and affordable way for general laboratories and pharmaceutical testing facilities to maintain a wide range of atmospheres and conditions, is the latest addition to the CLEAVER SCIENTIFIC range of laboratory products.
They can be used to keep samples in an inert gas (Nitrogen) environment, or can be used as an isolation glove box.
The boxes are made from polycarbonate and meet rigorous standards of cleanliness and durability, they also feature solvent welding which ensures a strong, airtight and leak-proof isolated area providing an effective barrier between operators and suspected contaminants.
Sealing is also enhanced thanks to the gaskets fixed on the side door.
They are designed with a 45 degree front slope which allows the operator an uninterrupted view of the workspace within and are available with two port I glove openings and in choice of sizes to suit most laboratories. Custom-built options are also available with additional ports and sizes to meet customers exact requirements.
All the boxes are supplied complete with a side access door as standard and additional accessories such as, air-lock (no-valves), pressure relief valve and inlet valve and air-lock with relief and inlet valves.

June,2008

NOVEL SOLUTIONS FOR FAST & ECONOMICAL ELECTROPHORESIS

Saving time and minimising effort in the laboratory, yet producing products which contribute toward high quality results, are the main objectives behind the development of the CLEAVER SCIENTIFIC range of electrophoresis products.
The range comprises horizontal and vertical gel electrophoresis tanks, blotting systems, comet assay, cellulose acetate, 2-D systems, power supplies, DNA sequencers and gel documentation systems. These are suitable for a variety of DNA, RNA and protein gel electrophoresis applications and analysis.

Constructed using the latest injection moulding technology and made from durable,

resistant materials, the tanks offer innovative and easy-to-use leak-proof gel casting to save time in the laboratory. Among the innovations and choices offered are more options for gel size, sample number and volume, along with five thicknesses of comb. Also, there are more preparative, high sample number and multi-channel pipette compatible comb options and combs which are height adjustable and warp proof.

There are also options for the type of comb with convenient double-sided, two combs in one and combination combs which include a loading guide on the reverse aiding sample loading. Gel sizes offered range from 7cm x 7cm up to 33cm x 45cm.
Cleaver Scientific also offer many other options to enhance the visibility of the wells during gel loading, such as using an inert dye which is used to stain the stacking layer of protein gels. Cont…

Cont…

Most tanks in the range have the option of rapid set-up cooling with no chiller required. These save time and expense in the laboratory and allow high resolution results to be achieved with the minimum of time and effort. For the economy conscious, most gel tanks have the option of buffer saving and casting of multiple gels at the same time, which also provides increased consistency.

Cleaver Scientific also offer products which provide important benefits for post electrophoresis applications, such as their popular Gel cutting tips. These are included as samples in with each gel tank and are an extremely useful tool for gene cloning.

Finally, to complete their range of tanks and systems, Cleaver offer a range of power supplies with increased current capability. These enable high intensity blotting and the connection of multiple gel tanks to one power supply, without compromising run conditions whilst also saving on bench space and cost.

May,2008

Uv STERILISATION CABINETS BRING CLEANROOM BENEFITS

The range of uvCAB UV Sterilisation Cabinets available from CLEAVER SCIENTIFIC, bring the advantages of a safe, nucleic acid-free environment, similar to having a ‘mini’ cleanroom within your laboratory. These cabinets provide a compact, low-cost and easily accessible area for setting-up PCR (Polymerase Chain Reactions), whilst minimising the potential for PCR reaction contamination.
The cabinets have powerful UV lights which serve to denature nucleic acids in 5 to 30 minutes making them unsuitable for amplication and contamination of PCR reactions. These lights are timer controlled and there are safety switches on the cabinet doors which automatically turn-off the UV lights when opened to prevent user exposure to UV light.
The cabinets also act as an efficient shield against beta radioactive emissions and can therefore be safely used with isotopes, such as 32P. The cabinets also include a white light which provides excellent visibility when working inside them.
uvCAB cabinets are available in two sizes. The Maxi version offers a large working space measuring 660 x 560 x 420mm (H x W x D) and offers a good sized cabinet for setting-up and also storage of PCR reactions along with the pipettes, racks and other equipment. For laboratories where space and budgets are particularly limited, the Mini Cabinet is ideal. It measures just 400 x 560 x 350mm (H x W x D) and contains two timer controlled UV bulbs.


Cont…
Accessories such as DNA and RNA removing solutions and compatible safety trays with disposable liners for use with both size of cabinets are also available.

March,2008

THERMAL AND GRADIENT THERMAL CYCLERS FOR MAXIMUM FLEXIBILITY

A range of cost-effective and easy-to-use thermal and gradient thermal cyclers have recently been added to the expanding range of laboratory products offered by CLEAVER SCIENTIFIC. CSL thermal and gradient thermal cyclers offer users the combination of outstanding flexibility and ease-of-use thanks to a host of standard features, yet they are competitively priced and compact so will suit most laboratories and most budgets.
They incorporate a very large easy-to-view control panel for intuitive, simple touch-screen programming of the entire protocol. The multiple programme options and reaction formats ensure excellent flexibility across a range of thermal cycling reactions and applications. Other features and benefits include heated lids, motorized on the gradient options, which effectively seal and reduce condensation in the sample vessel while their compact design means they occupy a small footprint and so minimising the valuable bench space taken up in the busy laboratory.
The gradient model has four quick-change block options for 0.2ml or 0.5ml tubes, 96 or 384 well plates and slides. The TC32/80 is the most economical ‘non-gradient’ model for when microplates or gradient are not required. The TC32/80 includes a combi block for 0.2ml and 0.5ml tubes.

January,2008

MICRODOC GEL DOC SYSTEM WITH LOW COST THERMAL PRINTER

A new, ultra-compact, transportable, inexpensive gel documentation system, which is easy-to-use and set-up, is the latest addition to the CLEAVER SCIENTIFIC range of electrophoresis products. The CSL MicroDOC is capable of producing high quality images thanks to its integral 16 bit CCD digital camera, which provides excellent resolution to 8.0 mega pixels. The flexibility of the microDOC system is enhanced because it can be used completely independent of a computer, or can be connected and controlled by a computer via USB connection.
The system enables a wide variety of images to be viewed from a new larger high definition 8” TFT liquid crystal colour display and then these images can be captured from agarose, other fluorescent gels, colorimetric gels, auto-radiography film and blotting membranes.
The system includes a 55mm ethidium bromide filter with a built-in safety switch to allow the UV Transilluminator to be turned-off when the door is open.
Files can be saved in a variety of formats ready for transfer to computer systems for storage and further analysis. The system now includes a 1GB flash card, allowing double the previous image capacity, and flash card reader enabling easy data transfer, while printing can be performed directly from MicroDOC using the included USB cable which also permits direct connection to a computer.
The compact and competitively priced Microdoc system will be particularly suited to laboratories where space and budgets are limited as it can be used completely independently of a PC.
Microdoc is available with optional UV Transilluminators in single and dual wavelengths and a choice of filter size of 20 x 20cm or 21 x 26cm.
In addition Cleaver Scientific off highly competitive prices for the Mitsubishi P93 series of thermal cyclers. For added convenience, printing of saved or live images can be performed directly from Microdoc.

November,2007

POWER SUPPLIES WITH INCREASED POWER

Cleaver scientific have substantially upgraded the specifications of their successful range of power supplies.
The omniPAC range of power supplies now features new microprocessor controlled models and increased current and power capability on pre-existing models.
Retaining their compact, ease of use and excellent price features, these power supplies now offer greater versatility and capacity to the researcher.
The biggest sellers in the range, models MP250 and MP300, now have increased power up to 150 watts and increased current up to 700mAmps. This enables the connection of greater numbers of electrophoresis systems to each power supply and the ability to use these for high intensity blotting, a feature not available on other general power supplies.
These power supplies now incorporate four sets of connecters with the potential to run four electrophoresis systems in parallel. They are suitable for use in cold rooms and can be set to run in constant voltage or current, and an optional time set to indicate the end of the run.
Two ultra compact new models compliment the range and are designed for labs operating with limited space and economy. These are the Mini150 and the Mini300 and are ideal for use with horizontal gel systems, such as those in the Cleaver Multisub range.
In addition, Cleaver Scientific have added a new model - MP-3AP - with massive 3 Amp current capability ideal for connecting multiple electrophoresis units or for high intensity blotting.
Two models – MP500V and MP-2000V are used for general and high voltage electrophoresis respectively and complete the range.

October,2007

NEW FORMULA GEL PROTEIN STAINING SOLUTION IS MORE SENSITIVE AND SAVES TIME

A ready-to-use protein gel staining solution which offers users a number of useful features and benefits over traditional Coomassie Blue stains, is the latest product to be introduced by electrophoresis specialists CLEAVER SCIENTIFIC. DyeHard™ enables rapid and ultra low background staining for proteins, yet it is as sensitive as a silver stain, detecting amounts of protein in gels to as low as 3 ng.
This new formula solution is designed to reduce the time and number of steps required to stain a protein gel. Dyehard is a new style stain which binds to the proteins within the gel, but not the gel itself. The result is increased sensitivity and the de-staining step needed when using traditional Coomassie Blue stains, is not required.
DyeHard gel staining solution, which is odourless, easy-to-dispose of and does not pollute the laboratory environment, is available in two conveniently sized, ready-to-use quantities of 500 ml and 1 litre.

September,2007

VERSATILITY AND CHOICE WITH A NEW RANGE OF FERMENTATION SYSTEMS

VERSATILITY AND CHOICE WITH A new range of economic programmable fermentation systems
Electrophoresis specialists Cleaver Scientific Limited (CSL) have introduced a new range of economic computer programmable fermentation systems.
The new software program consists of 15 easy steps. It has a fully integrated design and user-friendly control interface.
The software allows the user to easily and effortlessly download the experimental data to the computer. The fermentation program itself can be uploaded from either the fermentor controller or computer.
Further advantageous features of the software include real-time recording, a compact footprint, and very competitive pricing without compromising on features.
There are 4 capacity sizes of culture vessel available for the fermentation systems. These are 3, 5, 7 or 10 liters capacity.

August,2007

REVOLUTIONARY IN-SITU TRANSFECTION OF LIVING TISSUES

An in-situ transfection system, which, has been developed to provide direct transfection of living plant, animal cells and tissues, is the latest addition to the CLEAVER SCIENTIFIC range of laboratory products. The multiTRANF is the first transfection system to enable not only in vivo and in vitro transfection but also in-situ particle bombardment for genetic transformation of living tissues and provides users with features not available on other systems, for example ultra-fine 1 bar increment pressure control combined with low pressure transfection, necessary for keeping in situ tissues intact.
There are many convenience and time saving advantages in using in situ rather than in vitro or in vivo transfection to the research industry. Transfection of intact plants and animals such as drosophila embryos, allows the transfected organism to be studied without further preparations.
The multiTRANF system can be used with either Helium or Nitrogen gas and operates without the need for consumables, so users will benefit not only from minimal preparation time but also reduced initial experimentation costs, as well as lower on-going running costs.
Among the important features and benefits of the system are; simple and user-friendly microprocessor control using one-touch buttons, easy and accurate shooting pressure adjustment between 1-100 bars, with 1 bar increments. A 1-150 bars option is also available. Initial set-up on-site is simple and convenient while optimisation is not dependent on special kits. Start-up packs are available and users have the benefit of an extensive library of users and publications for reference.
MultiTRANF is ideal for use with most animal and plant tissues, embryos, yeast, bacteria, microbes and organelles.

June,2007

SEMI-DRY BLOTTERS ALLOW BLOTTING OF LARGER AND THICKER GELS

Electrophoresis specialists CLEAVER SCIENTIFIC LTD, (CSL) now offer researchers and scientists a wider choice and greater flexibility thanks to the introduction of a new range of semi-dry blotting products. Typically, most semi-dry blotters are primarily designed to blot thin protein gels up to 20 x 20cm in size. However, these new CSL blotters allow users to blot larger, thicker gel sizes and also provide for Western blotting of proteins and gels up to 33 x 45cm.
CSL semi-dry blotters provide faster transfer times and low buffer volumes for improved economy in the laboratory and they can also be used for Southern blotting (of DNA) and Northern blotting (of RNA).
Other important design features include a screw secured lid which provides precise control of pressure, particularly important when blotting thicker agarose gels. This enables CSL semi-dry blotters to be used for blotting not only of proteins, traditionally associated with this type of equipment, but also of nucleic acids.
The extended Cleaver Scientific range provides researchers and scientists with greater choice and flexibility. For example, 4 different sized models are available, starting with a mini semi-dry blotter, specifically designed to blot the most popular mini sized gel up to 10 x 10cm. Next is the standard size maxi semi-dry blotter, for gel sizes up to 20 x 20cm.

May,2007

HOTPLATES, STIRRERS, HOTPLATES / STIRRERS ARE CLEAN & COMPACT

A range of hotplates, stirrers and hotplate/stirrers which benefit from a compact, space-saving design, are the latest additions to the expanding range of laboratory products available from CLEAVER SCIENTIFIC. Bench top space is at a premium in many laboratories, so these units are ideal for crowded bench tops or inside cabinets.
All three models feature an exceptionally durable, easy-to-clean, chemically resistant white ceramic work surface which provides a large work surface of 19 x 19cm, yet they require a small ‘footprint’ of just 20 x 23cm. Advanced microprocessor controls with convenient easy-turn knobs allow quick, precise adjustment along with maintenance of speed and temperature. Safety indicator LED’s on the front panel indicate when the heating and/or stirring functions have been activated.
Thanks to their large square work surface, the units are compatible with a variety of popular sizes of borosilicate glass beakers, flasks, bottles and other commonly used vessels in the modern laboratory. They are also ideal for use with Electrophoresis systems from the Cleaver Scientific range. The stirrers provide a speed range of 60 to 1500 rpm while the hotplate temperature range is ambient +5 to 380°C. The hotplate/magnetic stirrer model
(CSL Hotplate) is supplied complete with a support rod for mounting thermometers and temperature probes.

April,2007

A GREAT NEW TOOL FOR GENE CLONING, GELX TIPS

THE CLEANER, SIMPLER AND QUICKER WAY TO EXCISE BANDS FROM GELS
Rapid, precise and contamination-free excision of spots and bands from gels is now a reality thanks to GelX, a new range of disposable gel excision tips recently introduced by electrophoresis specialists CLEAVER SCIENTIFIC.
GelX tips are designed to provide a cleaner, simpler and quicker method of removing bands from agarose and protein gels without the need for scalpels. GelX tips allow complete single handed operation throughout the gel excision process through “Press and Go” gel band excision, push button gel release and push button tip release.
Users simply fit the GelX tip to a 1000 ìl pipette, select the gel band, then press the tip into the gel. The gel slice is neatly extracted and contained into the tip. It can then simply be ejected into a tube or other container. The used tip can then be ejected and disposed of.

GelX tips are autoclavable and DNase and RNase free. Sterilised versions are also available.

The tips can be purchased in packs of 250 either bagged or racked and in two sizes, 4mm x 1mm or 6.5mm x 1mm.

March,2007

NEW HORIZONTAL ELECTROPHORESIS UNITS GUARANTEE LEAK PROOF SEALING

Easy-to-use, quick to set-up and capable of the highest quality, rapid and reliable sample resolution, these are the important features of a new range of injection moulded horizontal electrophoresis products, introduced by CLEAVER SCIENTIFIC LTD, (CSL).
Including a wide range of technical enhancements, the Cleaver scientific multisub horizontal range is the newest and most technically advanced range of DNA and RNA gel systems available.
CSL offer five different horizontal units in their multiSUB™ range, which incorporate sixteen different gel tray sizes, and unlike many other electrophoresis units, they benefit from an injection moulded construction which
provides a range of important benefits to the user. For example, a stronger, more durable high quality finish to better withstand the demands of the modern laboratory, yet they are lightweight, leak-proof and more competitively priced as a result of lower manufacturing costs. They also look attractive in the lab.
Central to the ease of use of the product is the guaranteed “plug and go” leak proof gel casting system. No agarose plugs or adjustments of gasket as advised by other manufacturers are necessary.
All multiSUB horizontal gel units are sold as complete systems and include all the required accessories. These include UV transparent gel trays with a choice of at least two different gel tray sizes per unit. This is a handy option when using expensive Low melting point agarose – the gel size can be matched to sample number requirements.
The researcher can also choose the types of comb they require at the time of purchase thanks to our free of charge comb substitution policy – again purchasing additional combs is not required and the multiSUB range offers the widest choice of combs available with more comb thickness, sample number, Multichannel pipette compatible and preparative choices. All combs are colour coded for thickness and easy identification, are height adjustable for added versatility and are completely warp proof due to a rigid comb back.
In addition reversible and double sided combs are available complete with either well- loading guide on the reverse side which help to channel the pipette tip into the well, or an additional different sample number comb for economy and space saving.
Two types of viewing guide are included, helping researchers when they come to load their samples.
And the list of benefits continues with increased sample capacity due to increased lane numbers, high sample number combs and stackable gel trays in the new multiSUB4 model, easy to replace and repair cassette style electrodes, power supply connecters and adapters which guarantee power supply compatibility and corrosion resistant high quality components.
Additional accessories offered include direct cooling packs to enhance resolution and allow faster run times, buffer saver blocks for added gel run economy, fluorescent rulers and gel leveling casters for perfectly level gels.

February,2007

NEW RANGE OF DIGITAL DRY BATHS

Electrophoresis specialists Cleaver Scientific Limited (CSL) offer a new range of digital dry baths. These have the added bonus of a microprocessor control and digital setting / temperature display. Plus, this range of baths can be used in a wide range of applications including within different laboratory settings, clinical, histology and molecular biology.

The desired temperature created by the high wattage heaters is regulated by the microprocessor, resulting in precise, accurate control. The arrow keys on the sloped panel, and values on the digital display, facilitate the straightforward procedure of setting up the required temperature. There is no need to check or readjust the thermometer afterwards.

The user calibration feature allows for easy calibration to in house standards when required. Additionally, there is an RS232 port for recording block temperature activity. An available data-logging software package is used to link the unit to a computer.

An extra and important feature is the stainless steel block chamber within the digital dry baths. These act as a heat sink with a uniform transfer of heat from the heating elements to the interchangeable blocks. As a result all the samples receive the same temperature treatment regardless of their position in the block due to the excellent block uniformity.

This flexible range also offers two bath models: A single block unit which will accept all of the standard blocks and a dual unit which will accept two standard blocks or one specially designed block. They come already supplied with a block lifter.

January,2007

MICRODOC – NOW WITH 8 INCH SCREEN AND 1GB FLASH CARD.

ULTRA-COMPACT GEL DOCUMENTATION SYSTEM – MICRODOC – NOW WITH 8 INCH SCREEN AND 1GB FLASH CARD.
A new, ultra-compact, transportable, inexpensive gel documentation system, which is easy-to-use and set-up, is the latest addition to the CLEAVER SCIENTIFIC range of electrophoresis products. The CSL MicroDOC is capable of producing high quality images thanks to its integral 16 bit CCD digital camera, which provides excellent resolution to 8.0 mega pixels.

The system enables a wide variety of images to be viewed from a new larger high definition 8” TFT liquid crystal colour display and then these images can be captured from agarose, other fluorescent gels, colorimetric gels, auto-radiography film and blotting membranes.
The system includes a 55mm ethidium bromide filter with a built-in safety switch to allow the UV Transilluminator to be turned-off when the door is open.

Files can be saved in a variety of formats ready for transfer to computer systems for storage and further analysis. The system now includes a 1GB flash card, allowing double the previous image capacity, and flash card reader enabling easy data transfer, while printing can be performed directly from MicroDOC using the included USB cable which also permits direct connection to a computer.

The compact and competitively priced Microdoc system will be particularly suited to laboratories where space and budgets are limited as it can be used completely independently of a PC.

December,2006

SIMPLE, RAPID LEAK-PROOF GEL CASTING

A new, easy-to-use, leak proof mini vertical gel casting system for protein PAGE separations and electroblotting applications, is the latest addition to the CLEAVER SCIENTIFIC range of electrophoresis products. The omniPAGE mini vertical gel electrophoresis unit is compatible with all major brands of precast gels and offers important features and benefits to users.

For example, a novel quick release clamp system provides a rapid and simple method for casting mini vertical gels. The patented sliding clamp mechanism means that the sealing and casting of gels is simply achieved by sliding two clamps on either side of the glass plates, a process which takes seconds. Also, as the unit is constructed using the latest injection moulded manufacturing techniques, a high quality finish combined with durability, strength and low cost, is assured.

To cast the gel, the glass plates are simply inserted into the unit and clamps slid across to seal. The insert is then transferred to the casting base and secured down onto an ultra-soft 10 shore hardness silicone mat. The gel solution is loaded and once it has set, the module is placed into the tank for running. This makes gel casting a simple four step procedure and considerably quicker than other systems available which either utilize complicated and unreliable screw mechanisms or require the transfer of glass plates.

Other features and benefits of the omniPAGE Mini system include; a reversible gasket which takes all 10 x 10cm and 10 x 8cm commercially available precast gels, durable 2mm thick glass plates with bonded spacers providing convenient and perfect set-up during gel casting. Cont…
Cont…
A cooling pack is also included as standard for rapid set-up cooling which enhances gel resolution giving ultra fine sample bands and parallel sample migration.

A wide range of comb and spacers are available, including preparative, 2-D, high sample number and multi-channel pipette compatible, colour coded in thicknesses of 0.5, 0.75, 1, 1.5 and 2mm. Finally, accessory blotting and tube gel modules are available which use the same outer tank and lid, while the blotting module has an increased three gel capacity and includes a novel hinged cassettes which eliminate shadow bands.

October,2006

uvCAB - UV STERILIZATION CABINETS FROM CLEAVER SCIENTIFIC

Offering the benefit of a clean room within your own laboratory for easy access and convenience, the Cleaver Scientific UV Sterilisation Cabinets provide a convenient area for setting up PCR reactions in a nucleic acid free environment thus limiting PCR reaction contamination.
Acting effectively as a low cost alternative to a clean room, the powerful UV lights on the cabinets denature nucleic acids in 5 to 30 minutes making them unsuitable for amplification and contamination of PCR reactions.
The cabinet incorporates safety features to prevent user exposure to UV light.
The UV lights themselves are timer controlled and there are safety switches on the cabinets doors which turn off the UV lights when opened.
The cabinets also act as an efficient shield of beta radioactive emissions
and can therefore be safely used with isotopes such as 32P.
The cabinets include a white light which provides excellent visibility when working within the cabinets.
Two sizes of cabinet are available.
The Maxi cabinet comes complete with four powerful timer controlled UV bulbs.
With a large working space of 660 x 560 x 420mm (H x W x D), it offers a good sized cabinet for setting up and also storage of PCR reactions and the pipettes, racks and other equipment used in their PCR reaction set up.
For laboratories with limited space and budget, the Mini Cabinet is ideal. It contains two timer controlled UV bulbs and has dimensions of 400 x 560 x 350mm (H x W x D)
Compatible safety trays with disposable liners for use with both cabinets are also available from Cleaver Scientific.

August,2006

ULTRA-COMPACT GEL DOCUMENTATION SYSTEM

A new, ultra-compact, transportable, inexpensive gel documentation system, which is easy-to-use and set-up, is the latest addition to the CLEAVER SCIENTIFIC range of electrophoresis products. The CSL MicroDOC is capable of producing high quality images thanks to its integral 16 bit CCD digital camera, which provides excellent resolution to 8.0 mega pixels.

The system enables a wide variety of images to be viewed from a clear 5.6” TFT liquid crystal colour display and then these images can be captured from agarose, other fluorescent gels, colorimetric gels, auto-radiography film and blotting membranes.

The system includes a 55mm ethidium bromide filter with a built-in safety switch to allow the UV Transilluminator to be turned-off when the door is open.

Files can be saved in a variety of formats ready for transfer to computer systems for storage and further analysis. The system includes a 512MB flash card and reader enabling easy data transfer, while printing can be performed directly from MicroDOC using the included USB cable which also permits direct connection to a computer.

The compact and competitively priced Microdoc system will be particularly suited to laboratories where space and budgets are limited as it can be used completely independently of a PC.

July,2006

WHEN YOU NEED SHIELDING FROM RADIOACTIVE COMPOUNDS

Safe and effective protection from radioactive compounds is an essential requirement in certain life science research laboratories, for example those handling either beta or gamma emitting materials used in the detection of nucleic acids and proteins, or other techniques, such as radioimmunoassay and metabolic studies.

CLEAVER SCIENTIFIC (CSL) have developed a wide range of over 120 Radiation Safety Products which provide optimum protection for laboratory personnel involved in applications where either Beta or Gamma emitting compounds are used. The range includes; shields, boxes, racks, waste bins, spillage trays and cabinets.

Flexibility and low cost are important requirements for many customers and CSL meet this demand by offering custom-built shields and boxes which are manufactured in a variety of shapes and sizes to suit most applications and budgets.
The storage boxes are ideal for waste materials and samples, interchangeable inserts can hold various sizes of tubes, such as micro-centrifuge, centrifuge tubes, scintillation vials, universals, cryotubes and falcon tubes. Drawstring heavy-duty waste bags are also available. Free standing bench top bins with hinged lids and anti-slip feet are ideal for short term storage of radioactive materials

In addition to the standard 10mm thick beta protection and 12mm thick lead impregnated gamma protection shielding is 35mm thick lead impregnated, providing gamma attenuation equivalent to 1.5mm thick lead and 70mm thick, offering gamma attenuation equivalent to 3.0mm thick lead.

The key features of these protection products are; clear optical for unobstructed view, choice of angle to suit location, most shields are available in small and large sizes, large flat base models for under-bench protection, curved base models which are compatible with safety spill trays and boxes and bins available with hinged lids in a variety of designs and sizes.

Finally, Cleaver Scientific can provide a DuoShield specifically for those applications which require safe protection from both beta and gamma emissions.

May,2006

SINGLE CELL ELECTROPHORESIS UNITS ARE FAST & CONVENIENT

New easy-to-use, rapid and reliable Comet Assay Electrophoresis ((deletion)) systems which meet the increasing demands for single cell gel electrophoresis techniques, are the latest addition to the CLEAVER SCIENTIFIC (CSL) range of products.

Single cell gel electrophoresis offers a fast and convenient way for scientists to evaluate DNA damage in the cell which could be caused by a variety of environmental factors, such as chemicals and molecules. Pharmaceutical, medical device companies and other general laboratories are discovering that Comet Assay is a highly sensitive and efficient means of assessing and quantifying DNA damage and repair in drug development applications.

These convenient, light-free, quick to set-up Comet Assay units are capable of high quality, rapid and reliable sample resolution and provide optimum flexibility for a variety of single cell electrophoresis techniques. They also offer the benefit of word removed a highly efficient cooling platform which can be easily connected to a chiller. This enables high capacity cooling of the slides and so enhances the performance and consistency of results.

The range comprises six different models, four of which are for use with 10, 20, 40 or 80 standard sized slides, while two models are for use with three and six respectively of the newly released Trevigen 96 Cometslide.

All units are completely non-transparent to light and offer a very convenient solution to keeping the samples out of direct light which can reduce the efficiency of the assay.

April,2006

RAPID USER FRIENDLY MINI VERTICAL GEL CASTING

Introducing a rapid, intuitive, easy to set up, leak proof mini vertical gel casting system from CLEAVER SCIENTIFIC LTD, (CSL).
The new omniPAGE mini vertical gel electrophoresis unit for protein PAGE separations and electroblotting contains the fastest and easiest system solution for casting mini vertical gels.

Constructed using the latest Injection moulded manufacturing which gives a product with a high quality finish, durability, strength and low cost, each clamping bar side has only one screw.

This is possible because the system contains a pressure bar which surrounds the glass plates, yet still allows cooling buffer to contact the gel, enhancing gel resolution.

To cast the gel, the glass plates are simply inserted into the unit and the single screws tightened. Once tightened the insert is transferred to the casting base and secured down onto an ultra soft 10 shore hardness silicone mat.
The gel solution is loaded and then once the gel has set, the module is simply placed into the tank for running. Gel casting is therefore a simple four step procedure.
This makes the system much simpler to cast gels than other systems available because there is a minimum number of steps required and no transfer of glass plates is necessary.

In addition, the omniPAGE Mini is built for durability because it has high impact components and progressive casting cams which allow for wear.

The omniPAGE Mini incorporates a reversible gasket which takes all 10 x 10cm and 10 x 8cm commercially available precast gels. The pressure bar enables parallel clamping of any precast gel for perfect gel resolution.

Other benefits of the omniPAGE Mini:-

A cooling pack is included as standard for rapid set up cooling. This also takes up buffer space so is a cooling pack / buffer saver pack combined. Use of the cooling pack enhances resolution giving ultra fine sample bands and parallel sample migration. No other unit has such an easy to use and rapid set-up cooling system.

omniPAGE has increased capacity; it is not only a dual system as up to four gels can be cast and run using a triple plate sandwich.

A wider range of comb and spacer choices than other systems is available, including preparative, 2-D, high sample number and Multi channel pipette compatible, colour coded for thickness in five thicknesses – 0.5, 0.75, 1, 1.5 and 2mm.

2mm thick glass plates prevent breakage and have bonded spacers for convenience and perfect set up during gel casting.

Accessory blotting and tube gel modules are available which use the same outer tank and lid. The blotting module has an increased three gel capacity and includes novel double hinged cassettes which eliminate shadow bands.

March,2006

NEW ELECTROPHORESIS UNITS ARE TECHNICALLY BETTER

Easy-to-use, quick to set-up and capable of high quality, rapid and reliable sample resolution, these are the important features of a new range of injection moulded electrophoresis products, introduced by CLEAVER SCIENTIFIC LTD, (CSL).

The Cleaver range comprises horizontal and vertical gel electrophoresis units, blotting units, comet assay and cellulose acetate systems, IEF systems, power supplies, DNA sequencers and gel documentation systems for DNA, RNA agarose gel electrophoresis, protein separations and analysis.

CSL offer five different horizontal units in their multiSUB™ range, and unlike other electrophoresis units, they benefit from an injection moulded construction which provides a range of important benefits to the user. For example, a stronger, more durable high quality finish to better withstand the demands of the modern laboratory, yet they are lightweight, leak-proof and more competitively priced as a result of lower manufacturing costs.

MultiSUB units offer researchers a greater variety of choice and flexibility for horizontal gel electrophoresis with more gel size and comb options. For example, each of the five units provide at least two choices of tray, while the three largest units have a choice of three. The mid-sized multiSUB unit offers an impressive 52 different off-the-shelf comb options, 20 of which are multi-channel pipette compatible. All the comb options are colour coded for easy identification, they are height adjustable and warp proof.

Two types of viewing guide are included, helping researchers when they come to load their samples. In addition reversible combs are available complete with well loading guide which help to channel the pipette tip into the well.

Other features and benefits of MultiSUB units include rapid set-up leak-proof gel casting using end dams which fit over the entire end of the tray and easy-to-replace cassette electrodes which eliminate the need for time consuming rewiring.

Additional accessories offered include direct cooling packs to enhance resolution and allow faster run times, buffer saver blocks, fluorescent rulers and gel leveling casters for perfectly level gels.